2,4-Dichloro-7H-Pyrrolo[2,3-d]pyrimidine CAS 90213-66-4 Purity >99.0% (HPLC) Tofacitinib Citrate Intermediate

Short Description:

Chemical Name: 2,4-Dichloro-7H-Pyrrolo[2,3-d]pyrimidine

Synonyms: 2,6-Dichloro-7-Deazapurine

CAS: 90213-66-4

Purity: >99.0% (HPLC)

Appearance: Off-White to Light Yellow Solid

Intermediate of Tofacitinib Citrate (CAS: 540737-29-9)

Contact: Dr. Alvin Huang

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E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

90213-66-4 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 2,4-Dichloro-7H-Pyrrolo[2,3-d]pyrimidine (2,6-Dichloro-7-Deazapurine) (CAS: 90213-66-4), intermediate of Tofacitinib Citrate (CAS: 540737-29-9).
Ruifu Chemical has been supplying pharmaceutical intermediates and APIs, fine chemicals more than 15 years.
Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase Tofacitinib Citrate intermediates, please contact us by e-mail: alvin@ruifuchem.com

Intermediates of Tofacitinib Citrate:

Tofacitinib Citrate	CAS 540737-29-9
4-Chloropyrrolo[2,3-d]Pyrimidine	CAS 3680-69-1
4-Chloro-7-Tosyl-7H-Pyrrolo[2,3-d]Pyrimidine	CAS 479633-63-1
(3R,4R)-1-Benzyl-N,4-Dimethylpiperidin-3-Amine Dihydrochloride	CAS 1062580-52-2
(3R,4R)-1-Benzyl-N,4-Dimethylpiperidin-3-Amine	CAS 477600-70-7
2,4-Dichloro-7H-Pyrrolo[2,3-d]Pyrimidine	CAS 90213-66-4
(2R,3R)-2,3-Bis[(4-methylbenzoyl)oxy]butanedioic acid compd. with (3R,4R)-N,4-dimethyl-1-(phenylmethyl)-3-piperidinamine	CAS: 477600-71-8

90213-66-4 - Chemical Properties:

Chemical Name	2,4-Dichloro-7H-Pyrrolo[2,3-d]pyrimidine
Synonyms	2,4-Dichloro-7H-Pyrrolo[2,3-δ]pyrimidine; 2,6-Dichloro-7-Deazapurine; Tofacitinib-8; 2,4-Dichloro-1H-Pyrrolo[2,3-d]pyrimidine; 4,6-Dichloro-4H-Purine
Stock Status	In Stock, Commercial Production
CAS Number	90213-66-4
Molecular Formula	C6H3Cl2N3
Molecular Weight	188.01 g/mol
Melting Point	249.0 to 253.0℃
Density	1.79±0.10 g/cm3
Solubility	Soluble in DMSO, Ethyl Acetate and Methanol. Slightly Soluble in Water
Storage Temperature	Store Long-Term at 2-8℃
COA & MSDS	Available
Origin of Product	Shanghai, China
Product Categories	Pharmaceutical Intermediates
Brand	Ruifu Chemical

90213-66-4 - Specifications:

Items	Specifications	Results
Appearance	Off-White to Light Yellow Solid	Light-Yellow Solid
Melting Point	249.0-253.0℃	250.0-251.0℃
Water by Karl Fischer	<0.50%	0.10%
Purity / Analysis Method	>99.0% (HPLC)	99.9%
1H NMR Spectrum	Conforms to Structure	Conforms
Conclusion	The product has been tested and complies with the given specifications
Application	Intermediate of Tofacitinib Citrate (CAS: 540737-29-9)

90213-66-4 - Package/Storage/Shipping:

Package: Fluorinated bottle, Aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃), well-ventilated warehouse. Keep away from sunshine; avoid fire and heat sources; avoid moisture. Store away from oxidizing agents.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

90213-66-4 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

90213-66-4 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

90213-66-4 - Risk and Safety:

Hazard Symbols T - Toxic
Risk Codes R25 - Toxic if swallowed
R36 - Irritating to the eyes
R36/37/38 - Irritating to eyes, respiratory system and skin.
R22 - Harmful if swallowed
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S28 - After contact with skin, wash immediately with plenty of soap-suds.
S36 - Wear suitable protective clothing.
UN IDs UN2811
HS Code 2933599099
Hazard Class IRRITANT

90213-66-4 - Application:

2,4-Dichloro-7H-Pyrrolo[2,3-d]pyrimidine (2,6-Dichloro-7-Deazapurine) (CAS: 90213-66-4) is used as a pharmaceutical intermediate, intermediate of Tofacitinib Citrate (CAS: 540737-29-9). Tofacitinib Citrate is an oral drug used for treating rheumatoid arthritis. Tofacitinib Citrate belongs to a class of drugs called Janus kinase (JAK) inhibitors. JAKs are enzymes (proteins) that regulate chemical signaling pathways that control biologic processes such as blood formation and the immune response that causes the pain, tenderness and swelling of inflammation. JAKs are found in many cells, especially stem cells in bones and joints. Inhibition of JAKs by tofacitinib prevents inflammation and tissue destruction that is associated with the inflammation of rheumatoid arthritis.